|
|
| |
 |
Magnetic Tweezers - SINGLE
MOLECULE MANIPULATION WITH MAGNETIC FIELDS
Contact: Prof. Dr. Dario Anselmetti |
| |
|
|
| |
|
Research Topic: Magnetic microbeads can be manipulated
and steered by external magnetic fields and allow
stretching and overwinding experiments with single (DNA) molecules at a sensitivity
level downto 0,001 pN. With our magnetic tweezers (MT) apparatus
(PicoTwist, Lyon - France) we investigate and quantify the binding of proteins, fluorescent dyes and chemotherapeutic agents to DNA. |
| |
|
|
| |
|
 |
| |
|
Images: MT measurement scheme (left), MT apparatus
(middle), and time evolution plot of molecular-length shortening during winding and packaging of double-stranded DNA in the presence of histone proteins (right). |
| |
|
|
|
|
References: ... see section Publications |
Last updated: 06.02.2017
|
|
