Logo Universität Frankfurt. Das Logo besteht aus dem Namen der Universität, sowie einer Goethe-Büste                Single Molecule Biophysics

 

 

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We study the structural organization of biomolecules in cells applying novel microscopic techniques that provide single-molecule sensitivity and a spatial resolution below the diffraction limit.

Photoswitches: Key molecules for subdiffraction-resolution fluorescence imaging and molecular quantification

(Review article in Laser & Photonics Reviews, 2009)

 

Fluorescence microscopy beyond the diffraction limit

(Review article in the Journal of Biotechnology, 2010)

dSTORM

Poster presentation, BPS Annual Meeting 2010

 

Recent papers

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Counting single proteins in dense clusters

Lando, Endesfelder et al., Open Biology 2012                     

 

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Single-particle tracking of TNF receptor 1 in live cells

Heidbreder et al., BBA Molecular Cell Research 2012                     

 

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3D, tomographic super-resolution imaging of thick tissue

Nanguneri et al., PLoS ONE 2012                     

 

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Super-resolution fluorescence imaging of chromosomal DNA in intact cells

Zessin et al., J Struct Biol 2012                     

 

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Coordinate-based colocalization analysis of pointillistic super-resolution data

Malkusch et al., Histochem Cell Biol 2012

 

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** NEWS TICKER **

Oct 2nd 2012: Meike successfully defended her PhD thesis -- Congratulations!!

September 2012: SwissPALM @EPFL and PicoQuant Single-Molecule Meeting @Berlin

August 2012: a manuscript on cluster analysis of HIV particles has been accepted by Histochemistry

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 and Cell Biology

August 2012: a manuscript on fluorogenic probes for nucleic acid detection has been accepted by ChemComm

August 2012: group retreat at Buchen, Odenwald

July 2012: EPA/IUPAC meeting at Coimbra & award of the EPA-PPS paper prize for this PPS paper

July 2012: Optics Within Life Science (www.owls2012.org) at Genua

June 2012: our study on the lateral mobility of single TNF-receptors in live cells using single-particle tracking was accepted by BBA Molecular Cell Research

June 2012: our work on quantitative single-molecule imaging of CENP-A in S. pombe was accepted for publication in Open Biology

June 2012: ELMI @ Leuven with two posters by Patrick and Franzi

May 2012: tomoSTORM accepted for publication in PlosONE! (link)

May 2012: ISBI @ Barcelone

April 2012: FOM @ Singapore, with two presentations by Ulrike and Mike

Mar 2012: a review article on live cell super-resolution imaging in Annual Reviews of Physical Chemistry

Feb 20th 2012: Ulrike successfully defended her PhD thesis -- Congratulations!!

Feb 2012: getting prepared for the 2012 BPS meeting in San Diego

Feb 2012: Anika and Carmen join the group for their Master Thesis -- Welcome!!

Jan 2012 : Franzi is awarded a PhD fellowship by the Graduate School of Life Sciences -- Congrats!!

Dec 2012: 2 papers accepted: super-resolution of chromosomal DNA (Journal of Structural Biology) and coordinate-based colocalization analysis (Histochemistry and Cell Biology)

Nov 2011: Bianca and Christoph join the group for their Master Thesis, and Franzi joins the group for a PhD -- Welcome!!

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